リコピンは心臓の健康に良いですか?

リコピン has strong antioxidant properties and is currently widely used in the fields of food, medicine and cosmetics. It can improve the body'の状態と複数の側面から免疫力を強化します。本稿では、分析の入り口となるリコピンの概要を紹介し、リコピンの健康効果を多面的に分析します。

1 .リコピンの概要

Lycopene was first discovered in tomatoes and tomato products, as well as in fruits such as grapefruit. It is one of the pigments in ripe tomatoes and an important component of carotenoids. In 1989, scholars discovered that among all carotenoids, lycopene had the highest singlet oxygen quenching activity, and thus lycopene has been widely valued. Ginlin [1] studied the metabolism and absorption of lycopene and found that it can prevent prostate cancer and many kinds of tumors as well as the corresponding cardiovascular diseases. This view confirms that lycopene has high preventive value.

リコピン独特の構造と含まないβの-iononeサイクル構造をβ-caroteneこのため、体内に入ってもビタミンaには変化しない。また、リコピンは脂溶性が高く、水、エタノール、メタノールなど多くの物質に不溶です。リコピンは非常に安定ではなく、外部環境の影響によって容易に酸化され、分解される。その安定性に影響を与える主な要因は、酸素、温度、金属イオン、光、酸および抗酸化物質です。

Generally speaking, lycopene has a higher absorption rate than α-carotene and β-carotene. Natural lycopene is mainly in the all-trans configuration, while the lycopene in the body is mainly in the cis configuration, and it will not be affected by the configuration of natural lycopene in the food consumed. If the patient has intestinal disease or a lack of iron, zinc or protein, it will cause a disorder of lycopene absorption. For natural lycopene, heat processing can be used to convert the trans structure to the cis structure, thereby meeting the body'の栄養ニーズと体を増やします&#リコピンの39の吸収率。

Lycopene is commonly found in the liver, adipose tissue and kidney tissue of the body, and is also distributed in the ovaries and prostate of the human body. There is currently little medical research on the metabolites of lycopene, but small amounts of lycopene metabolites can be found in serum tests and skin and milk tests on the human body.

2健康機能の導入

2.1ボディを高めます'の酸化ストレス容量と抗炎症効果

chen yueqinらは、ラットを用いて、放射線を電離した後の酸化ストレス時に、レンズ損傷を減少させるためのリコピンの効果を研究し、高用量のリコピンがラットのレンズ上皮細胞のアポトーシスを効果的に減少させることを発見した。スーパーオキシドジスムターゼは、体を反映することができます's antioxidant damage, and X-ray irradiation causes a gradual decrease in superoxide dismutase levels in rats. After lycopene was administered orally, the above indicators could be effectively improved. Moreover, the higher the concentration of lycopene applied, the better the body&#リコピンが体を改善することができることを確認した酸化ストレスに抵抗する39の能力&#抗酸化力39;s。酸化的損傷は、癌や心血管・脳血管疾患の増加の主な原因の1つであり、リコピンは強い抗酸化能力を持つことが実験的研究で示されています。

Bronchial asthma, or asthma for short, is a heterogeneous disease characterized by chronic airway inflammation and airway hyperresponsiveness. It is also the most common respiratory disease in clinical practice. After the onset of the disease, the expression of inflammatory factors increases. However, by taking advantage of the biological properties of lycopene, the risk of vascular disease can be reduced. Jin Bingrong et al. [3] studied the role of lycopene in the treatment of asthma and found that after treatment, the levels of IL-4, IL-5 and IL-13 in patients improved significantly. This result further confirms that lycopene has a strong anti-inflammatory effect, can effectively inhibit the expression of inflammatory factors, and improve the physical indicators of patients.

2.2心臓、脳および血管の保護

Cardiovascular diseases are currently common and highly prevalent among the middle-aged and elderly, and have a significant impact on the physical health and quality of life of patients. Currently, drug therapy and surgery are important measures to ensure the healthy functioning of the heart. In addition to clinical disease treatment, more attention needs to be paid to the protection of the cardiovascular system. Lycopene has strong antioxidant properties and is of great significance for the protection of the cardiovascular system. Lycopene can remove blood vessel waste, regulate plasma cholesterol levels, protect low-density lipoprotein from oxidation, and repair cells that have undergone oxidation in a timely manner. It is also beneficial for the formation of intercellular matrix, thereby improving the overall toughness of the patient' s血管。

tian y, miaoら[4]は、高脂肪飼料を脂肪マウスに与え、リコピンを介入し、マウスを観察した#39;s blood glucose, blood lipids, body mass and body fat percentage. The pathological changes in the glands were verified using staining methods. The results showed that lycopene can effectively inhibit the weight gain of obese mice under a high-fat diet, while also effectively improving the fasting blood glucose, glucose tolerance and blood lipid levels in mice, and reducing the vacuolation of pancreatic tissue in mice, confirming the positive effect of lycopene on lipid metabolism. In addition, lycopene'の抗酸化特性は、局所脳虚血を改善する上で重要な役割を果たすことができます。主にその抗酸化特性を利用してフリーラジカルを除去し、グリア細胞の活性阻害を減少させ、それによって患者の脳出血後の灌流損傷領域を減少させます。この考え方は、臨床医学における医療の発展を促進する上で重要な役割を果たしてきました。

2.3皮膚の保護

Lycopene, a carotenoid, has a higher antioxidant effect than vitamins C and E, and is therefore widely used in the anti-aging field. By using lycopene, you can effectively avoid UV damage caused by prolonged sun exposure and reduce damage to the deep tissue of the skin. According to the free radical theory, normal body cells form excessive free radicals during metabolism, which accelerates aging. Therefore, the targeted removal of free radicals can delay aging. Lycopene'の抗酸化特性を効果的にフリーラジカルをクエンチすることができます。抗酸化力はβ-カロチンの2倍以上で、天然のアンチエイジング物質です。呉円谷らになった。[5]の役割を勉強中の皮肤がん発症のの红素にネズミ年に実施したアンケート调査にトマトの红素シグナリング経路Keap1-Nrf2を蘇らせる皮肤がん発症诱导の话术や炎症を抑えるラットに確認リコピンは皮肤腫瘍発症のを予防する保護効果もある肌に残ってしまいます。

リコピン粉現在、アンチエイジングフェイシャルマスクの製造に使用されています。生産プロセスにリコピンを組み込むことで、dpphラジカル阻害率を大幅に向上させることができます。李トンらは、リコピン抗老化フェイシャルマスクに関する研究を行った。その結果、リコピンのdpphフリーラジカル除去率は76.76%と高く、保湿と抗酸化作用が優れていることがわかった。この研究結果は、植物のフェイシャルマスクの製造にリコピンを使用することができ、優れたアンチエイジング効果があることを確認しました。

2.4免疫力を高める

Immunity is the key to maintaining good health and the main protection against disease. In the elderly, immunity generally decreases, which in turn exacerbates the occurrence of cardiovascular and cerebrovascular diseases, respiratory diseases, and digestive diseases. In response to this situation, biological research on boosting immunity needs to be actively strengthened. Lycopene has strong antioxidant properties, can repair oxidized cells in the body, activate immune cells, and protect phagocytes, reducing oxidative damage to phagocytes. Chen Yao et al. [7] studied the immune function of lycopene, and fed mice different doses of lycopene, and observed the cellular immunity, humoral immunity and macrophage phagocytic function of the mice after 30 days. It was found that the NK cell activity and phagocytic index of the macrophages in mice taking high doses of lycopene were significantly higher, and in addition, it could effectively improve the mice'sの遅延型過敏症能力。

免疫システムはボディである&#防衛の39のメインライン。免疫システムが破壊されると、細菌やウイルスが体内に侵入しやすくなり、患者に炎症反応を経験させます。tリンパ球を介した特異的な免疫応答は、健康を維持するために重要である。遅延型過敏症に関する研究では、リコピンはマウスの腫れを効果的に増加させることができます' sのつま先、そのマウスを示す'の免疫応答は徐々に改善されています。マウスでは、リコピンがt細胞サブセットの数を増やし、免疫調節の役割を果たすことが確認されています。それはまた、臨床研究で発見されている場合、ボディ's lycopene intake is low, cell proliferation in the peripheral blood will be affected. This is currently an important indication that lycopene can enhance the body' s免疫システムです。

3応用分野の拡大

In vitro studies have found that lycopene intake does not cause serious adverse reactions, and lycopene has been widely used in food supplements and cosmetics. In recent years, the gradual growth of the sub-healthy population has led to a new understanding of health issues, so health products and sports supplements are now accepted by most people. Lycopene, as a substance with strong antioxidant properties, is widely used in health products and sports supplements. The use of substances containing lycopene can effectively prevent oxidation, delay aging, enhance immunity, and regulate blood lipid and blood sugar indicators in the body. This substance can be made into tablets, oils, or capsules. In addition to health products and sports supplements, lycopene is also used in the production of cosmetics. Due to its strong antioxidant properties, it plays an important role in delaying skin aging and ensuring fair skin.

Lycopene can also be used in the food and beverage industry. Using lycopene in sauces and seasonings and in the production of dairy products can ensure the nutrition of dairy products while also having a certain health effect. Lycopene is also found in meat products and cooking oil. It can improve the preservation effect of meat, reduce meat spoilage and the growth of internal microorganisms. Adding lycopene to cooking oil can effectively alleviate oil fission and ensure food safety.

4結論

要約すると、リコピンは重要な抗酸化特性を有し、体を改善する上で重要な役割を果たしています'の免疫系、心血管や脳血管疾患を防止し、皮膚を保護します。その応用分野を分析した結果、リコピンは日常生活と臨床医学の両方において重要な価値があり、今後の研究と推進に値することが確認されました。

参照

[1] jiang l .ヒト前立腺がんに対するリコピンの抑制効果および機構に関する研究[d]。『河北医科大学』河北医科大学、2019年。

[2] chen yq, liu c, liu jy, et al。酸化ストレスを有するラットにおけるレンズ損傷の軽減に及ぼすリコピンの効果[j]。^ a b c d e f『仙台市史』通史編(2016年)、41 -51頁。

[3] jin bingrong, che nan, li liangchang, et al。抗喘息効果とリコピンのメカニズムに関する研究[j]。中国免疫学ジャーナル,2020,36(3):365-368。

[4] tian yimiao, li rui, zhu ruyuan, et al。ブドウ糖と脂質代謝に対するリコピンの影響のTLR4規制肥満モデルラットで/シグナリング経路MyD88 / NF -κB膵臓組織か[J]中国漢方薬、2020年、51(16):4236-4243。

[5] wu yuanyuan, yu suyun, wei zhonghong, et al。リコピンは、keap1-nrf2シグナル伝達経路を活性化することによって、マウスの誘導性皮膚がんの発生を阻害する[j]。中国の薬理学と毒物学のジャーナル,2021,35(10):751。

【6】李童、董延輝、葉自成。リコピンアンチエイジングフェイシャルマスクの調製[j]。広州化学工業,2020,48(21):63-65。

[7] chen yao, lu lianhua, lv zhimin, et al。リコピンの免疫増強と抗酸化作用に関する研究[j]。^『人事興信録』人事興信録、2018年(平成30年)4月24日、339 - 339頁。