dマンノーズパウダーバルク

dマンノース粉末バルクとは何ですか?

dマンノースは単糖である。グルコースの異性体であり、グルコース輸送タンパク質を介して細胞内に入る。マンノースはヘキソキナーゼによって細胞内で触媒され、マンノース-6-リン酸(m6p)を産生し、これはホスホマンノーイソメラーゼ(pmi)によって解糖系に、あるいはホスホマンノームターゼ(pmm2)によって糖鎖化経路に触媒される。

柑橘類の皮、桃やリンゴなどの果物、象牙のヤシの種子、酵母、紅藻、血清グロブリン、卵状ムチン、結核菌などに含まれる糖鎖には少量の遊離マンノースが存在する。

green spring technologiesは、dマンノース粉末バルクを生成します 高純度、低エンドトキシン含有、低コロニー数、低重金属。ich q3dに規定されている重金属について、10億分の1 (ppb)以下の濃度で試験されています。

green springには、優れたr & dチーム、経験豊富な生産チーム、プロの販売チームがあります。私たちは体系的な品質管理システムを持っており、iso、haccp、およびその他の品質基準に厳密に従った生産を組織しています。halal、kosher、cosmos、brc、ifs、fda、isoなど多くの認証を取得しています。私たちは、信頼できるサードパーティのテストレポートを提供することができます。

规格: 

規制:

euの規制に準拠しています。

Benefits:

Inhibiting Tumour Growth

A study reported in Nature 2018 found that D mannose powder can inhibit tumour growth by suppressing glucose metabolism by screening the effects of different hexoses on the growth of tumour cell lines. Lui Lei's team sought to explore whether various hexoses affect tumour immunity. Through screening, the researchers found that high concentrations of D-mannose were able to degrade PD-L1 protein in TNBC cells. In-depth mechanistic studies revealed that D-mannose treatment could promote the activation of AMPK, which promoted the phosphorylation of the S195 site of PD-L1 protein. The phosphorylation of this site can weaken the glycosylation of PD-L1 protein, which leads to the degradation of PD-L1 protein through proteasome.

Further studies revealed that D-mannose-mediated degradation of PD-L1 also inhibited the DNA damage repair process in tumour cells, resulting in a facilitating effect on radiotherapy for TNBC. In a mouse model of TNBC, the combination of oral D mannose and PD-1 antibody treatment significantly prolonged the survival of hormonal mice and increased CD8+ T cell infiltration and granzyme B expression in the tumour. Similarly, the combination of oral D-mannose and ionising radiation significantly inhibited tumour growth in vivo and significantly enhanced the efficacy of radiotherapy in TNBC mice.

In conclusion, this study revealed a new function of D-mannose - degradation of PD-L1 protein and reported for the first time the facilitating effect of D-mannose on immunotherapy and radiotherapy of TNBC, which provides a new strategy for the clinical treatment of TNBC.

Cell Recognition

D Mannose powder is one of the important components of cell surface glycosylation that can participate in cell recognition and interaction with the external environment.

Immunomodulation

D Mannose plays an important role in the immune system and is involved in intercellular signaling, inflammatory regulation, and activation of immune cells.

Antiviral

D mannose powder can interact with certain viral structural proteins to inhibit viral invasion and replication processes.

Applications:

For Feed Product：

Overuse of antibiotics in farming leads to the proliferation of resistant bacteria as well as pollution of the environment. Studies have demonstrated that D mannose powder can inhibit the infection of Salmonella in young chickens without side effects. Adding D mannose powder to livestock and poultry feed has the effect of inhibiting the proliferation of pathogens in the intestinal tract, protecting the health of animal intestinal tract, increasing immunity and disease resistance, and improving feed utilization.

For Health Products:

D Mannose powder has been used clinically as a glyconutrient. It can be widely distributed in body fluids and tissues, especially in the nerves, skin, testes, retina, liver, and intestine. The body can directly use mannose to synthesize glycoproteins and participate in immune regulation. In recent years, a series of surprising physiological activities of mannose, a common monosaccharide, have been revealed, including anti-inflammation, inhibition of bacterial infections, alleviation of diabetes, anti-tumor, etc. D mannose powder has been used as an additive in nutraceuticals.