Natural Xanthohumol in Hops Extract Enhances Bone Health Product Upgrades

5月08,2025
カテゴリ:Nutraceutical Ingredients

Withthe growing emphasis on healthy living, modern consumers are increasingly prioritizing bone nutrition and daily care. Among numerous natural plant-derived active ingredients, xanthohumol—a compound sourced from hops—has emerged as a focal point, garnering significant attention from both research and industry sectors.

 

Xanthohumol is a unique natural flavonoid compound found exclusively in hops. It possesses excellent antioxidant properties and demonstrates promising potential in maintaining cellular health. Research indicates this compound helps support osteoblast activity while regulating osteoclast activity, offering new avenues for developing bone-related dietary supplements and functional foods. Currently, multiple international patents have been secured for xanthohumol applications, indicating broad industrialization prospects.

 

Adhering to the philosophy の“Natural Science, Healthy Future,” Green Spring Technology now introduces high-purity, premium-quality xanthohumol powder extracted from hops. We are committed to providing stable, reliable natural ingredient solutions for global clients, empowering brands to develop more innovative and market-competitive bone nutrition products, and jointly advancing the health industry's upgrade.

 

Hops Extract 5% Xanthohumol


1 Green Spring Technology High-Purity Xanthohumol: Multi-Pathway Regulation of Bone Metabolism and Cell Differentiation—An Innovative Raw Material Solution Backed by In Vitro Evidence

Xanthohumol, a flavonoid compound derived from hops, demonstrates distinct in vitro activity in regulating bone metabolism. Its multi-target mechanism influences osteoblast and osteoclast differentiation processes, demonstrating development potential as a functional bone nutrition ingredient.

 

At the molecular level, xanthohumol significantly upregulates Runx2 expression and promotes differentiation markers (e.g., ALP, osteocalcin) in osteoblasts. Simultaneously, it inhibits adipogenesis by suppressing the PPARγ signaling pathway, thereby promoting mesenchymal stem cell differentiation toward osteogenic differentiation. Regarding antioxidant effects, anthohumol activates the Nrf2-ARE pathway to enhance intracellular antioxidant enzyme expression (e.g., HO-1, NQO1), mitigating oxidative stress impacts on osteoblast activity.

 

In osteoclast regulation, anthohumol inhibits RANKL-induced NF-κB activation by reducing IκBα degradation and p65 nuclear translocation. Simultaneously, it inhibits Ca²⁺ oscillations and the NFATc1 signaling pathway, downregulating key osteoclast differentiation markers (e.g., TRAP, CTSK). MAPK pathway studies indicate that anthoxymol suppresses ERK, p38, and JNK phosphorylation, thereby affecting c-Fos and NFATc1 transcriptional activity.

 

Green Spring Technology employs proprietary extraction processes to provide epigallocatechin gallate (EGCG) raw material with >98% purity, featuring distinct HPLC fingerprint profiles and batch consistency. This material exhibits excellent stability in both aqueous and lipid-soluble systems, making it suitable for developing various dosage forms such as solid beverages and soft capsules. We provide comprehensive in vitro cellular experimental data support, including osteoblast differentiation assays, osteoclast formation inhibition studies, and antioxidant activity measurements, serving as a reference for product development.

 

2 Green Spring Technology Xanthohumol: Multi-Pathway Regulation of Cellular Function, Empowering Next-Generation Bone Nutrition Innovation

Xanthohumol, a natural bioactive compound derived from hops, has garnered significant attention in the field of bone nutrition in recent years. Its multi-targeted properties in cellular signaling and metabolic regulation offer new avenues for developing innovative bone nutrition products.

 

Research indicates that xanthohumol interacts with multiple cellular signaling pathways to maintain the healthy equilibrium of bone tissue. By influencing RANKL-mediated cellular signaling, it participates in regulating various cellular functional pathways including NF-κB, Ca²⁺/NFATc1, and MAPK, thereby supporting bone health at the molecular level.

 

At the mechanistic level, p-Cresol has been found to regulate IκB protein metabolism, influencing NF-κB's intracellular localization. Simultaneously, it modulates Ca²⁺ signaling frequency, positively affecting NFATc1 activity. Furthermore, p-Cresol exhibits regulatory effects on EPK1/2 and c-fos expression within the MAPK pathway. These multifaceted mechanisms provide a scientific rationale for p-coumaric acid's application in bone nutrition.

 

Green Spring Technology employs innovative extraction processes to produce high-purity, highly stable p-coumaric acid raw materials. Our products exhibit excellent biocompatibility and compatibility, making them suitable for dietary supplements, functional foods, and specialized dietary products. We are committed to providing partners with premium natural raw material solutions, jointly advancing the development of bone nutrition products toward greater efficiency and innovation.

 

3 Innovative Bone Nutrition Solutions: Green Spring Technology's High-Purity Xanthohumol Powder, Empowering Product Upgrades

As modern society increasingly prioritizes healthy aging, the bone nutrition sector faces renewed demand for product innovation. Xanthohumol—a bioactive flavonoid from hops—has demonstrated multi-pathway potential in regulating bone metabolism through extensive cellular studies, opening new avenues for advanced bone health products.

 

Green Spring Technology leverages advanced extraction and purification techniques to introduce high-purity, high-stability xanthohumol powder with the following core advantages:

✨ Purity >98%, backed by complete HPLC detection spectra and a rigorous quality control system ensuring batch-to-batch consistency;

✨ Excellent bioavailability and compatibility, suitable for diverse formulations including solid beverages, soft capsules, and tablets;

✨ Comprehensive in vitro cellular experimental data support, including multi-dimensional research outcomes on osteogenic differentiation, antioxidant activity, and cellular metabolism.

 

We are committed to providing partners with scientifically validated, commercially valuable raw material solutions that help clients:

· Break through the homogenized competition of traditional bone nutrition products by creating innovative offerings with differentiated competitive advantages;

· Gain end-to-end technical support spanning ingredient mechanism research to product development;

· Accelerate product R&D cycles to swiftly respond to market demands.

 

Green Spring Technology collaborates with industry partners to leverage natural science and technology, jointly advancing the professionalization and scientific upgrading of bone health products. We deliver more effective and safer nutritional solutions for consumers.

 

Contact us at helen@greenspringbio.com or WhatsApp: +86 13649243917 for complimentary samples and technical documentation.

 

参照

[1] 陳氏陳氏陳氏陳氏陳氏骨粗鬆症の健康経済評価の現状、課題、提言[j]。中国内分泌・代謝学会誌,2021,

[2] 王弐。抗骨粗鬆症薬の効果と進歩[j]。中国医学ジャーナル,2021,56(11):1189-1192。

[3] 林Canbin。骨粗鬆症の治療におけるビスホスホネート薬の異なる種類の臨床的有効性[j]。日刊合理的な薬物使用、2021年まで、14(32):109-111。

[4] 袁春燕、任穆連。閉経後の骨粗鬆症に対する性ホルモン療法[j]。産婦人科プラクティカル・ジャーナル,2020,36(7):494-497。

[5] チョン・ギョンミン-チョン・ギョンミンとも。植物フラボノイドの骨粗しょう症に対する効果に関する研究[j]。中国骨粗鬆症学会誌,2021,27(10):1529-1533。

[6] liu xiaoyan, xia tian shuang, dong zhiming, et al。骨粗しょう症の治療におけるホップの応用と展望[j]。2020日刊製薬練習38(6):492-495。

【7】Aggarwal D、Upadhyay SK、シン r,et al.最近の特許  治療  活動   of   xanthohumol:  ホップ(humulus lupulus l .)由来のプレニル化カルコノイド。 [J]。 Pharmパットを追っていく2021、お金10 (1):37-49

[8] okamoto k, nakashima t, shinohara m,et al. osteoimmunol - 免疫系と骨格系を統合する概念的枠組み[j]。2017年Physiol牧師さん、97(4):1295-1349。

[9] muruganandan s, ionescu am, sinal cj。岐路に立った 脂肪細胞と破骨細胞の分化プログラムの 未来治療角度  [J]。int j mol sci,2020 21(7): 2277。

ついて来て
一覧に戻る
Prev

Natural Hop Extracts Empower Innovation in Bone Health Products

Natural Hop Extract Fuels Innovation in Wellness Product Formulations

推薦情報

詳細が必要な場合は、連絡してください.